In the present study we investigated the effect of hydroalcoholic extract of fruit of Terminalia chebula (TCE) in alleviating the diabetic impotency in rats. Male wistar albino rats were classified into two groups as normal control and diabetic group. Normal control group rats were injected with distilled water (1ml/kg) while in diabetic group, diabetes mellitus was induced by intraperitoneal injection of Alloxan monohydrate ( 120 mg/kg) freshly dissolved in normal saline solution.21 days after diabetes induction, the rats in diabetic group were individually tested for sexual potency by pairing them with oestrus female rat. Diabetic rats showed a significant decline in the sexual potency as compared to the normal control groups. Following this, the diabetic rats were divided into five groups and treated orally as: diabetic control group with distilled water 1 ml/day, TCE-200 group with TCE 200 mg/kg, TCE-400 group with TCE 400 mg/kg, TCE-800 group with 800 mg/kg and standard group with sildenafil citrate 5 mg/kg for 21 days. Their sexual behavior was evaluated on 14 th and 21st day of respective treatment. The study revealed dose dependent improvement in all the parameters of sexual behavior against diabetic control group, reflecting increased potency. These results suggest that TCE have beneficial activity against diabetic impotency in rats.This observed activity of TCE may be due to the presence of phytoconstituents like tannins , alkaloids, saponins, flavonoids. Further studies required to determine the exact molecular mechanism of action of Terminalia chebula.
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